Benztropine mesylate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

苯扎托品是一种抗胆碱能化合物，用于患者减少抗精神病化合物治疗的副作用。

Benzatropine is an anticholinergic drug used in patients to reduce the side effects of antipsychotic treatment. Benzatropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor, but not rigidity and bradykinesia. (In Vitro):Benztropine mesylate (0.1-10 μM; 72 hours) treatment inhibits the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine mesylate reduces the size as well as the number of mammospheres significantly in a dose-dependent manne.Benztropine mesylate inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors.Benztropine mesylate induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced re-myelination.(In Vivo):Benztropine mesylate (1.5 mg/kg; daily; for 3 weeks; Balb/c mice) treatment significantly reduces both tumor size and tumor weight in a 4T1 mouse model.

Cell Viability Assay Cell Line:MDA-MB-231 cells Concentration:0.1 μM, 0.625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation Time:72 hours Result:Inhibited the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM.Cell Proliferation Assay Cell Line:MDA-MB-231 cells Concentration:0, 1, 2, 5 μM Incubation Time:4-6 days Result:Suppressed mammosphere formation and self-renewal capacities of BCSCs in a dose-dependent manner in vitro.

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NSC 169913

GPCR/G Protein

Dopamine Receptor

DAT

Neurological Disease

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132-17-2

403.53

C21H25NO·CH4SO3

>98% (HPLC)

Ethanol: 81 mg/mL (200.72 mM); Water: 81 mg/mL (200.72 mM); DMSO: 50 mg/mL (123.9 mM)

CN1[C@@H]2C[C@@H](OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@H]1CC2.OS(C)(=O)=O

(1R,3r,5S)-3-(benzhydryloxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate

(-20℃)

With Ice Pack

≥ 2 years